Francis Lorraine Marshall, the partner of the victim, appeared in the Adelaide Magistrates Court on Monday charged with murder.

She was remanded in custody to appear again on Friday where an application for bail will be considered.

The arrest and subsequent court appearance comes after a near six-year investigation into the tragic incident that shocked the local community.

The arrest also follows a public plea from the family following the event.

The 46-year-old's death on Friday October 25, 2002 is believed to be the first murder in Victor Harbor.

Ms Liston's body was discovered by her 12-year-old daughter, Jennifer, at about 3.15pm when she returned home to their Ives Crescent Home from the Victor Harbor R-7 School.

Ms Liston, a mother of five, had allegedly been stabbed, shot several times and bludgeoned with a blunt object earlier that day, with police confirming that there was no sign of forced entry.

Although a tragic and shocking event, many neighbours have come to terms with the incident during the six years that have passed.

"They've all put it behind them," a resident said on behalf of other people still living in the street.

It also appears that the latest turn of events has not fazed the Ives Crescent locals.

"I don't think that it's affected any of us," the resident added.

Although locals may have put the death of Ms Liston behind them, the results of the court case may bring some added closure to the family.

"Mum was just a great person and she didn't deserve to die the way she died," Bernadette's son David said in an earlier interview.

"She was the most precious mother, sister and friend that ever lived on this Earth, she would have done anything for anyone," he added.

The knife used to stab Ms Liston was taken from her kitchen and left at the scene, and police have still been unable to locate the small calibre firearm used to shoot the childcare worker.